Selective cytotoxicity of 4-S-cysteaminylphenol on follicular melanocytes of the black mouse: rational basis for its application to melanoma chemotherapy
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:6272436
We have previously shown that 4-S-cysteaminylphenol (4-S-CAP) causes a significant inhibition of in vivo melanoma growth. To clarify the mechanism of the in vivo antimelanoma effect, this study evaluated the cellular and subcellular changes of follicular melanocytes after s.c. administration of 4-S-CAP on the lumbar areas of black and albino mice. 4-S-CAP produced a prompt, selective swelling and lysis of melanocytes, resulting eventually in the necrosis of melanocytes and the depigmentation of black hair follicles. None of the degenerative changes were seen in melanocytes and keratinocytes of control albino follicles. Comparison of melanocytes in black and albino follicles revealed that melanin synthesis is highly active in the melanocytes of black follicles while melanin and tyrosinase synthesis is not seen in the melanocytes of albino follicles. The findings indicate that the selective melanocytotoxicity of 4-S-CAP is manifested by lysis and necrosis of cells which are actively engaged in melanin synthesis. 4-S-CAP appears to provide a new modality for rational chemotherapy of malignant melanoma.
- Research Organization:
- Sapporo Medical College, Japan
- OSTI ID:
- 6272436
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 12; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CHEMOTHERAPY
DISEASES
DRUGS
ENZYMES
GROWTH
HAIR
HYDROXY COMPOUNDS
HYDROXYLASES
INHIBITION
LYSIS
MAMMALS
MEA
MELANIN
MELANOMAS
MICE
NECROSIS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PHENOLS
PIGMENTS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SKIN
SYNTHESIS
THERAPEUTIC USES
THERAPY
THIOLS
TYROSINASE
USES
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CHEMOTHERAPY
DISEASES
DRUGS
ENZYMES
GROWTH
HAIR
HYDROXY COMPOUNDS
HYDROXYLASES
INHIBITION
LYSIS
MAMMALS
MEA
MELANIN
MELANOMAS
MICE
NECROSIS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PHENOLS
PIGMENTS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SKIN
SYNTHESIS
THERAPEUTIC USES
THERAPY
THIOLS
TYROSINASE
USES
VERTEBRATES