Depigmentation of black guinea pig skin by topical application of cysteaminylphenol, cysteinylphenol, and related compounds
Journal Article
·
· J. Invest. Dermatol.; (United States)
Phenol and catechol were combined with sulfur to develop new melanocytotoxic agents. Among these synthetic compounds, 4-S-cysteaminylphenol (4-S-CAP) and 4-S-cysteinylphenol (4-S-CP), which showed an in vivo antimelanoma effect, were evaluated for cytotoxicity to normal epidermal melanocytes using hydroquinone (HQ) as the control. Topical application of 4-S-CAP on the skin of black guinea pigs revealed a marked depigmentation of black skin. 4-S-Cysteinylphenol also showed some depigmenting potency. 2-S-Cysteinylhydroquinone, which was made by combining cystine with HQ, on the other hand, did not show any depigmenting effect. Depigmentation of black skin by 4-S-CAP appeared to derive from: a decrease in the number of functioning melanocytes; a decrease in the number of melanosomes synthesized within the melanocytes and transferred to keratinocytes; and destruction of the membranous organelles of the melanocytes. None of these degenerative changes was observed in the keratinocytes, indicating the selective effect of 4-S-CAP on melanocytes.
- Research Organization:
- Sapporo Medical College, Japan
- OSTI ID:
- 6775368
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 1; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pigmented guinea pig skin irradiated with Q-switched ruby laser pulses. Morphologic and histologic findings
Selective cytotoxicity of 4-S-cysteaminylphenol on follicular melanocytes of the black mouse: rational basis for its application to melanoma chemotherapy
Ultrastructural demonstration of chemical modification of melanogenesis in hairless mouse skin
Journal Article
·
Sat Dec 31 23:00:00 EST 1988
· Arch. Dermatol.; (United States)
·
OSTI ID:6535430
Selective cytotoxicity of 4-S-cysteaminylphenol on follicular melanocytes of the black mouse: rational basis for its application to melanoma chemotherapy
Journal Article
·
Mon Jun 15 00:00:00 EDT 1987
· Cancer Res.; (United States)
·
OSTI ID:6272436
Ultrastructural demonstration of chemical modification of melanogenesis in hairless mouse skin
Journal Article
·
Sun Jan 31 23:00:00 EST 1982
· Anat. Rec.; (United States)
·
OSTI ID:5132152
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
CARBOXYLIC ACIDS
CYSTEINE
EPIDERMIS
EPITHELIUM
GUINEA PIGS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PHENOL
PHENOLS
PIGMENTS
RODENTS
SKIN
THIOLS
TISSUES
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
CARBOXYLIC ACIDS
CYSTEINE
EPIDERMIS
EPITHELIUM
GUINEA PIGS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PHENOL
PHENOLS
PIGMENTS
RODENTS
SKIN
THIOLS
TISSUES
TOXICITY
VERTEBRATES