Phenolic melanin precursors provide a rational approach to the design of antitumor agents for melanoma

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Pigment Cell Res.; (United States)

DOI:https://doi.org/10.1111/j.1600-0749.1989.tb00155.x· OSTI ID:6071256

Jimbow, K; Miura, T; Ito, S; Ishikawa, K

A unique biological property of the melanocyte, melanin synthesis may permit a rational approach to design agents for better management of malignant melanoma. This in vivo and in vitro study examined the selective melanocytotoxicity and antimelanoma effects of phenolic compounds, cysteinylphenol (CP), cysteaminylphenol (CAP), and related compounds, and found (1) that both 4-S-CP and 4-S-CAP are melanin precursors, (2) that 4-S-CAP possesses a marked depigmenting potency with selective destruction of melanocytes in black follicles, and (3) a significant inhibition in the protein synthesis and tumor growth of B16 melanoma. Importantly, a whole body autoradiography indicated that these phenolic melanin precursors are selectively incorporated into melanoma tissues after i.p. administration.

• Research Organization: Univ. of Alberta, Edmonton (Canada)
• OSTI ID: 6071256
• Journal Information: Pigment Cell Res.; (United States), Journal Name: Pigment Cell Res.; (United States) Vol. 2:1; ISSN PCREE
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550901 -- Pathology-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
AROMATICS
BIOSYNTHESIS
CHEMOTHERAPY
DISEASES
DRUGS
HYDROXY COMPOUNDS
IN VITRO
IN VIVO
MAMMALS
MELANIN
MELANOMAS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
PIGMENTS
PRECURSOR
RODENTS
SYNTHESIS
THERAPY
TOXICITY
VERTEBRATES