S-phenyl-N-acetylcysteine in urine of rats and workers after exposure to benzene
Journal Article
·
· J. Anal. Toxicol.; (United States)
An HPLC method for the determination of S-phenyl-N-acetylcysteine in urine is described. The sensitivity is 6 mumol/L (CV = 9%) urine. Exposure of rats to six different concentrations of benzene, ranging from 0-30 ppm, was highly associated with urinary excretion of S-phenyl-N-acetylcysteine (r = 0.86) and with total phenol (r = 0.81). A background level of phenol was found in urine of both non-exposed rats and of non-exposed referents. However, no background excretion of S-phenyl-N-acetylcysteine was found, either in rats or in humans. In urine of exposed rats, the level of S-phenyl-N-acetylcysteine was approximately five times lower than the phenol level. Workers occupationally exposed to benzene, showing high levels of urinary phenol, revealed low concentrations of urinary S-phenyl-N-acetylcysteine. The biological monitoring of industrial exposure to benzene by determination of S-phenyl-N-acetylcysteine in urine is not better than the determination of phenol in urine.
- Research Organization:
- Univ. of Nijmegen, The Netherlands
- OSTI ID:
- 6271665
- Journal Information:
- J. Anal. Toxicol.; (United States), Journal Name: J. Anal. Toxicol.; (United States) Vol. 11:3; ISSN JATOD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACIDS
CHROMATOGRAPHY
CLEARANCE
CYSTEINE
DISTRIBUTION
DRUGS
EXCRETION
GLUTATHIONE
HYDROCARBONS
HYDROXY COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MATERIALS
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PEPTIDES
PERSONNEL
PHENOLS
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RENAL CLEARANCE
RODENTS
SEPARATION PROCESSES
THIOLS
TISSUE DISTRIBUTION
TOXICITY
URINE
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACIDS
CHROMATOGRAPHY
CLEARANCE
CYSTEINE
DISTRIBUTION
DRUGS
EXCRETION
GLUTATHIONE
HYDROCARBONS
HYDROXY COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MATERIALS
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PEPTIDES
PERSONNEL
PHENOLS
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RENAL CLEARANCE
RODENTS
SEPARATION PROCESSES
THIOLS
TISSUE DISTRIBUTION
TOXICITY
URINE
VERTEBRATES
WASTES