Mutagenic activity and polycyclic aromatic hydrocarbon levels in urine of workers exposed to coal tar pitch volatiles in an anode plant
Journal Article
·
· Carcinogenesis (N.Y.); (United States)
The mutagenicity of urinary extracts and the excretion of PAH from workers occupationally exposed to coal tar pitch volatiles in an anode plant were analyzed. Mutagenicity of the urinary extracts was measured by means of the plate test using S. typhimurium strain TA 98. After concentration, hydrolysis and reduction of the urine samples, PAH levels were measured by high resolution gas chromatography/mass spectrometry. No significant difference was found in the mutagenicity of the urinary extracts of non-smokers occupationally exposed to PAH as compared with the controls. Low PAH concentrations were found in the urine of the exposed subjects, which lends further support to the negative results obtained with the Ames test. The increase of urinary PAH excretion, in relation to occupational exposure, was mainly due to the less mutagenic, low molecular weight compounds.
- Research Organization:
- Univ. of Padua, Italy
- OSTI ID:
- 5176467
- Journal Information:
- Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 5; ISSN CRNGD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AROMATICS
BACTERIA
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHROMATOGRAPHY
CLEARANCE
COAL TAR
ENVIRONMENTAL EXPOSURE
EXCRETION
GAS CHROMATOGRAPHY
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
MASS SPECTROSCOPY
MATERIALS
MICROORGANISMS
MOLECULAR WEIGHT
MUTAGEN SCREENING
MUTAGENS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PERSONNEL
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SEPARATION PROCESSES
SPECTROSCOPY
TAR
URINE
WASTES
016000 -- Coal
Lignite
& Peat-- Health & Safety
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AROMATICS
BACTERIA
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHROMATOGRAPHY
CLEARANCE
COAL TAR
ENVIRONMENTAL EXPOSURE
EXCRETION
GAS CHROMATOGRAPHY
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
MASS SPECTROSCOPY
MATERIALS
MICROORGANISMS
MOLECULAR WEIGHT
MUTAGEN SCREENING
MUTAGENS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PERSONNEL
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SEPARATION PROCESSES
SPECTROSCOPY
TAR
URINE
WASTES