Preparation of 1-(1-oxyl-2,2,6,6-tetramethyl-3,4-dehydropiperidyl-4)silatrane for pharmacokinetic studies
The authors study the preparation of silatranes for pharmacokinetic study. To prepare the first representative of the spin-labeled silatranes, the authors reacted 1-iodosilatrane with bis(1-oxyl-2,2,6,6-tetramethyl-3,4-dehydropiperidyl-4)mercury. The end of the reaction was monitored by the EPR method. In the EPR spectrum of the end product a triplet signal is observed indicating a hyperfine splitting of the unpaired electron with a nucleus of one nitrogen atom. A mass spectrometric analysis of the reaction product confirmed the formation of the required title silatrane (I). Results of the examination of the possible use of I in pharmacokinetic studies are discussed. The distribution of I in organs and tissues of rats is shown.
- Research Organization:
- Irkutsk Institute of Organic Chemistry (USSR)
- OSTI ID:
- 6271150
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:8; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
AMINES
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
DISTRIBUTION
ELECTRON SPIN RESONANCE
ETHERS
HETEROCYCLIC COMPOUNDS
HYPERFINE STRUCTURE
KINETICS
MAGNETIC RESONANCE
MAMMALS
METABOLISM
MULTIPLETS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SILICON COMPOUNDS
PHARMACOLOGY
PIPERIDINES
PYRIDINES
RATS
REACTION KINETICS
RESONANCE
RODENTS
SYNTHESIS
TISSUE DISTRIBUTION
VERTEBRATES