Transformation of Syrian hamster embryo cells by synfuel mixtures
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
Existing Syrian hamster embryo (SHE) cell-transformation assay methods were modified to allow the assay of complex synfuel mixtures. A shale oil, high-molecular-weight, high-boiling distillates from two different solvent-refined coal (SRC) processes, and two crude petroleum samples caused transformation of SHE cells. Chemical fractionation of SRC-11 heavy distillate and assay of resultant fractions allowed detection of significant transforming activity in chemical fractions, where such activity had not previously been observed. The polyaromatic-hydrocarbon-enriched fraction, neutral aliphatic hydrocarbon fraction, and neutral tar fraction all showed a positive response in the SHE assay. Earlier data was confirmed showing that both the tar fractions (basic and neutral) and the soluble basic fractions from both SRC processes and shale oil contained genetically active materials.
- Research Organization:
- Pacific Northwest Lab., Richland, WA
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6268255
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 11; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
02 PETROLEUM
020600 -- Petroleum-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BIOASSAY
EMBRYONIC CELLS
FRACTIONATION
HAMSTERS
HYDROCARBONS
MAMMALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SCREENING
SEPARATION PROCESSES
SRC PROCESS
VERTEBRATES
016000 -- Coal
Lignite
& Peat-- Health & Safety
02 PETROLEUM
020600 -- Petroleum-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BIOASSAY
EMBRYONIC CELLS
FRACTIONATION
HAMSTERS
HYDROCARBONS
MAMMALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SCREENING
SEPARATION PROCESSES
SRC PROCESS
VERTEBRATES