Comparison of in vivo carcinogenesis and in vitro genotoxicity of complex hydrocarbon mixtures

Conference · Mon Aug 01 04:00:00 EDT 1983

OSTI ID:5972969

Pelroy, R A; Mahlum, D D; Frazier, M E; Renne, R A; Stewart, D L; Chess, E K

The genetic activity and carcinogenicity of synthetic fuels were compared. In vitro tests consisted of the standard Ames histidine reversion test with Salmonella typhimurium TA-98, the Chinese hamster ovary (CHO) forward mutation and the Syrian hamster embryo (SHE) transformation assays. In vivo carcinogenesis and tumorigenesis test consisted of the initiation/promotion (I/P), mouse skin-painting (initiation phase) and chronic mouse skin-painting assays. Comparisons involving only crude fuels (i.e, not fractionated by chemical class) included: Wilmington crude petroleum versus Paraho shale oil versus solvent refined coal (SRC)-I and -II liquids. Chemical class fractions from SRC-II heavy distillate (HD; boiling point 550-850/sup 0/F), and the SRC-II 850+/sup 0/F distillate bottoms were prepared and assayed for genetic and carcinogenic activity. 15 references, 14 figures, 3 tables.

• Research Organization: Pacific Northwest Labs., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5972969
• Report Number(s): PNL-SA-11582; CONF-8308109-3; ON: DE85007503
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AROMATICS
AZAARENES
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGEN SCREENING
COAL LIQUEFACTION
COAL LIQUIDS
CONDENSED AROMATICS
DATA
DISEASES
ENERGY SOURCES
EXPERIMENTAL DATA
FLUIDS
FOSSIL FUELS
FUELS
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INFORMATION
LIQUEFACTION
LIQUIDS
MINERAL OILS
MUTAGEN SCREENING
NEOPLASMS
NUMERICAL DATA
OILS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
PARAHO PROCESS
PETROLEUM
POLYCYCLIC AROMATIC AMINES
POLYCYCLIC AROMATIC HYDROCARBONS
SCREENING
SHALE OIL
SOLVENT-REFINED COAL
SRC PROCESS
SRC-II PROCESS
THERMOCHEMICAL PROCESSES