Epiderma carcinogenesis studies of synthetic fossil fuel materials in mice: comparison and correlation with in vitro genotoxicity

Conference · Fri Jun 01 04:00:00 EDT 1984

OSTI ID:6178447

Renne, R A; Pelroy, R A; Frazier, M E; Wilson, B W; Mahlum, D D; Smith, L G; Buschbom, R L

Epidermal tumorigenic response in mice to solvent fractions of heavy distillate (HD) from a solvent-refined coal (SRC-II) process indicated that the basic tar and neutral tar were the most carcinogenically potent fractions. Assays of another SRC-II coal liquid that had been fractionally distilled indicated that the epidermal carcinogenicity of this material for mouse skin is due to that portion boiling above 700/sup 0/F, and that the carcinogenic potency of the material increases with boiling point. With some notable exceptions, carcinogenicity data for materials and fractions in chronic skin-painting assays correlated with genotoxic activity in microbial (Ames/Salmonella) and mammalian cell culture (Syrian hamster embryo) assay systems, and with carcinogenicity data in initiation/promotion (I/P) assays in mouse skin. 25 references, 6 figures, 2 tables.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6178447
• Report Number(s): PNL-SA-11519; CONF-8406217-1; ON: DE85000840
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
CARCINOGENESIS
CHEMICAL ANALYSIS
COAL LIQUIDS
EPIDERMIS
EPITHELIUM
FLUIDS
FUELS
LIQUIDS
MAMMALS
MICE
ORGANS
PATHOGENESIS
RODENTS
SKIN
SOLVENT-REFINED COAL
SYNTHETIC FUELS
TISSUES
TOXICITY
VERTEBRATES