Pathogenesis and modification of cadmium-induced lung injury in mice

Thesis/Dissertation · Sun Jan 01 04:00:00 EST 1984

OSTI ID:6267715

Martin, F M

The effects of hyperoxia on Cd-damaged mouse lungs were studied to determine if there was potentiation of the injury by O/sub 2/. Female Balb/c mice were exposed to aerosols of 0.65% CdCl/sub 2/ for one hour by the nose-only method while control animals were exposed to water aerosols. Immediately after, some animals were placed in 70 to 80% O/sub 2/ for days, while others were left in room air. Cd exposed animals had significantly increased levels of hydroxyproline/lung, indicative of increased collagen secretion and hence fibrosis. The Cd + O/sub 2/ exposed animals had even higher levels showing the synergistic effects of O/sub 2/. Experiments on the effects of prednisolone and X radiation in modifying the Cd-induced injury were also done but neither showed any alteration of the Cd-induced lesion. Pretreatment with 1 mg/kg of Cd i.p. for 4 days before Cd inhalation was also shown not to alter fibrosis. Investigations were made of the long term effects of Cd + O/sub 2/ on the fibrotic lesion. Mechanisms of the action of Cd, and a literature survey are included. The study provides an experimental model for the interactions of two inhalants, Cd and O/sub 2/, and elucidates the behavior of different cell populations following injury.

• OSTI ID: 6267715
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CADMIUM
COMPARATIVE EVALUATIONS
ELEMENTS
INJURIES
LUNGS
MAMMALS
METALS
MICE
NONMETALS
ORGANS
OXYGEN
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SYNERGISM
VERTEBRATES