Reducing bone lead content by chelation treatment in chronic lead poisoning: an in vivo X-ray fluorescence and bone biopsy study

Journal Article · Tue Jan 31 23:00:00 EST 1989 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(89)80086-6· OSTI ID:6265438

Batuman, V; Wedeen, R P; Bogden, J D; Balestra, D J; Jones, K; Schidlovsky, G

A stained-glass artist with longstanding exposure to lead presented with neuropsychiatric symptoms. He was evaluated before and after chelation treatment by the CaNa2 EDTA lead mobilization test, iliac crest bone lead measurement, and in vivo tibial X-ray fluorescence (XRF). The three methods showed a progressive fall in body lead stores during chelation therapy in association with improvement in symptoms and a fall in blood lead and zinc protoporphyrin levels. In vivo tibial XRF is a safe, rapid, and noninvasive technique for detecting excessive body lead burdens. XRF measurement of bone lead content is a practical method for monitoring the efficacy of therapy as well as for establishing the diagnosis.

• Research Organization: Veterans Administration Medical Center, East Orange, NJ (USA)
• OSTI ID: 6265438
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 48:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOPSY
BODY
BODY BURDEN
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL ANALYSIS
CHRONIC EXPOSURE
DIAGNOSTIC TECHNIQUES
EDTA
ELEMENTS
LEAD
MAMMALS
MAN
METABOLISM
METALS
NONDESTRUCTIVE ANALYSIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
SKELETON
UPTAKE
VERTEBRATES
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS