In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700090304· OSTI ID:5681127

Wielopolski, L; Ellis, K J; Vaswani, A N; Cohn, S H; Greenberg, A; Puschett, J B; Parkinson, D K; Fetterolf, D E; Landrigan, P J

Lead concentrations (microgram/g wet weight) in human bone (tibia) were measured noninvasively in vivo employing an X-ray fluorescence technique. Forty-five workers who had been subjected to chronic industrial exposure were found to have a mean bone lead content of 52.9 micrograms/g wet weight (0 to 198 micrograms/g). In addition to bone lead content, blood lead, body burden of lead as assessed by urinary lead excretion after EDTA chelation, zinc protoporphyrin, and unstimulated urinary lead excretion were evaluated. The results suggest that the in vivo measurement of tibia lead content may serve as an acceptable indicator of body lead burden and provide a practical technique for lead screening purposes. The correlation coefficient between X-ray fluorescence findings and lead excretion following Ca-EDTA administration is 0.69; p less than 0.001.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 5681127
• Journal Information: Am. J. Ind. Med.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LEAD
ECOLOGICAL CONCENTRATION
TISSUE DISTRIBUTION
SKELETON
X-RAY FLUORESCENCE ANALYSIS
BIOLOGICAL INDICATORS
BLOOD
CHRONIC EXPOSURE
EXCRETION
IN VIVO
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
URINE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
CLEARANCE
DISTRIBUTION
ELEMENTS
MATERIALS
METALS
NONDESTRUCTIVE ANALYSIS
ORGANS
WASTES
X-RAY EMISSION ANALYSIS
550501* - Metabolism- Tracer Techniques