In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure

Journal Article · Tue Dec 31 23:00:00 EST 1985 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700090304· OSTI ID:5681127

Wielopolski, L; Ellis, K J; Vaswani, A N; Cohn, S H; Greenberg, A; Puschett, J B; Parkinson, D K; Fetterolf, D E; Landrigan, P J

Lead concentrations (microgram/g wet weight) in human bone (tibia) were measured noninvasively in vivo employing an X-ray fluorescence technique. Forty-five workers who had been subjected to chronic industrial exposure were found to have a mean bone lead content of 52.9 micrograms/g wet weight (0 to 198 micrograms/g). In addition to bone lead content, blood lead, body burden of lead as assessed by urinary lead excretion after EDTA chelation, zinc protoporphyrin, and unstimulated urinary lead excretion were evaluated. The results suggest that the in vivo measurement of tibia lead content may serve as an acceptable indicator of body lead burden and provide a practical technique for lead screening purposes. The correlation coefficient between X-ray fluorescence findings and lead excretion following Ca-EDTA administration is 0.69; p less than 0.001.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 5681127
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 3; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
CHRONIC EXPOSURE
CLEARANCE
DISTRIBUTION
ECOLOGICAL CONCENTRATION
ELEMENTS
EXCRETION
IN VIVO
LEAD
MATERIALS
METALS
NONDESTRUCTIVE ANALYSIS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANS
PERSONNEL
SKELETON
TISSUE DISTRIBUTION
URINE
WASTES
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS