Body burdens of lead in hypertensive nephropathy

Journal Article · Fri Sep 01 04:00:00 EDT 1989 · Archives of Environmental Health; (USA)

DOI:https://doi.org/10.1080/00039896.1989.9935898· OSTI ID:5024313

Osterloh, J D; Selby, J V; Bernard, B P; Becker, C E; Menke, D J; Tepper, E; Ordonez, J D; Behrens, B ^[1]

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1. Univ. of California, San Francisco (USA)

Chronic lead exposure resulting in blood lead concentrations that exceed 1.93 mumol/l (40 micrograms/dl) or chelatable urinary lead excretion greater than 3.14 mumol (650 micrograms) per 72 h has been associated with renal disease. A previous study had found greater chelatable urine lead excretion in subjects with hypertension and renal failure than in controls with renal failure due to other causes, although mean blood lead concentrations averaged 0.92 mumol/l (19 micrograms/dl). To determine if chelatable urinary lead, blood lead, or the hematologic effect of lead (zinc protoporphyrin) were greater in hypertensive nephropathy (when hypertension precedes elevation of serum creatinine) than in other forms of mild renal failure, we compared 40 study subjects with hypertensive nephropathy to 24 controls having a similar degree of renal dysfunction due to causes other than hypertension. Lead burdens were similar in both the study and control groups as assessed by 72-h chelatable urinary lead excretion after intramuscular injection of calcium disodium EDTA (0.74 +/- 0.63 vs. 0.61 +/- 0.40 mumol per 72 h, respectively), and by blood lead (0.35 +/- 0.23 vs. 0.35 +/- 0.20 mumol/l). We conclude that subjects from a general population with hypertensive nephropathy do not have greater body burdens of lead than renal failure controls.

• OSTI ID: 5024313
• Journal Information: Archives of Environmental Health; (USA), Journal Name: Archives of Environmental Health; (USA) Vol. 44:5; ISSN AEHLA; ISSN 0003-9896
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BODY
BODY BURDEN
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHELATING AGENTS
CHRONIC EXPOSURE
DISEASES
EDTA
ELEMENTS
ENVIRONMENTAL EXPOSURE
HYPERTENSION
KIDNEYS
LEAD
MAMMALS
MAN
METABOLISM
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PRIMATES
SYMPTOMS
UROGENITAL SYSTEM DISEASES
VASCULAR DISEASES
VERTEBRATES