Chronic renal failure with gout: a marker of chronic lead poisoning

Journal Article · Sat Sep 01 00:00:00 EDT 1984 · Kidney Int.; (United States)

DOI:https://doi.org/10.1038/ki.1984.175· OSTI ID:5606409

Craswell, P W; Price, J; Boyle, P D; Heazlewood, V J; Baddeley, H; Lloyd, H M; Thomas, B J; Thomas, B W

EDTA (calcium disodium edetate) lead mobilization and x-ray fluorescence (XRF) finger bone lead tests were done in 42 patients with chronic renal failure and without persisting lead intoxication. Nineteen of 23 patients with gout and 8 of 19 without gout had positive EDTA lead mobilization tests. Those patients with gout excreted significantly more excess lead chelate than those without gout. In the gout group 17 patients denied any childhood or industrial exposure to lead. They had a greater number of positive tests and excreted significantly more excess lead chelate than 14 patients with neither gout nor lead exposure. These results confirm that gout in the presence of chronic renal failure is a useful marker of chronic lead poisoning. Of 27 patients with positive lead mobilization tests, only 13 had elevated XRF finger bone lead concentrations (sensitivity 48%). Three of 15 patients with negative lead mobilization tests had elevated XRF finger bone lead concentrations (specificity 80%). Although the XRF finger bone lead test is a convenient noninvasive addition to the diagnostic evaluation of patients with chronic renal failure and gout, its application is limited due to the lack of sensitivity of the method.

• Research Organization: Royal Brisbane Hospital, Queensland, Australia
• OSTI ID: 5606409
• Journal Information: Kidney Int.; (United States), Journal Name: Kidney Int.; (United States) Vol. 26:3; ISSN KDYIA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BIOLOGICAL MARKERS
BODY
CARBOXYLIC ACIDS
CHELATES
CHELATING AGENTS
CHEMICAL ANALYSIS
CHRONIC EXPOSURE
CLEARANCE
COMPLEXES
DIAGNOSIS
DISEASES
EDTA
ELEMENTS
ENVIRONMENTAL EXPOSURE
EXCRETION
KIDNEYS
LEAD
METALS
NONDESTRUCTIVE ANALYSIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RETENTION
SKELETAL DISEASES
UROGENITAL SYSTEM DISEASES
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS