Estimates of radiation absorbed dose for intraperitoneally administered iodine-131 radiolabeled B72. 3 monoclonal antibody in patients with peritoneal carcinomatoses

Journal Article · Sun Sep 01 04:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:6262334

Larson, S M; Carrasquillo, J A; Colcher, D C; Yokoyama, K; Reynolds, J C; Bacharach, S A; Raubitchek, A; Pace, L; Finn, R D; Rotman, M ^[1]

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1. Nuclear Medicine Service, Sloan-Kettering Memorial Cancer Center, New York, NY (United States)

Using a newly available model for determining estimates of radiation absorbed dose of radioisotopes administered intraperitoneally, the authors have calculated absorbed dose to tumor and normal tissues based on a surgically controlled study of radiolabeled antibody distribution. Ten patients with peritoneal carcinomatosis received intraperitoneal injections of the murine monoclonal antibody B72.3 radiolabeled with 131I. Biodistribution studies were performed using nuclear medicine methods until laparotomy at 4-14 days after injection. Surgical biopsies of normal tissues and tumor were obtained. The marrow was predicted to be the critical organ, with maximum tolerated dose (200 rad (2 Gy) to marrow) expected at about 200 mCi (7.4 GBq). In patients with large intraperitoneal tumor deposits, the tumor itself is an important source tissue for radiation exposure to normal tissues. Local hot-spots for tumor-absorbed dose were observed, with maximum tumor-absorbed dose calculated at 11,000 rad (11 Gy) per 100 mCi (3.7 GBq) administered intraperitoneal; however, tumor rad dose varied considerably. This may pose serious problems for curative therapy, especially in patients with large tumor burdens.

• OSTI ID: 6262334
• Journal Information: Journal of Nuclear Medicine; (United States), Journal Name: Journal of Nuclear Medicine; (United States) Vol. 32:9; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
IMMUNOLOGY
IMMUNOTHERAPY
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAPERITONEAL INJECTION
IODINE 131
IODINE ISOTOPES
ISOTOPES
MEDICINE
MEMBRANES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
PERITONEUM
RADIATION DOSES
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SEROUS MEMBRANES
SPECIFICITY
THERAPY