Peritoneal carcinomatosis: imaging with intraperitoneal injection of I-131-labeled B72. 3 monoclonal antibody
Journal Article
·
· Radiology; (United States)
Monoclonal antibody (MoAb) B72.3 is reactive with a variety of carcinomas such as colorectal and ovarian carcinoma and not reactive with a range of normal tissues in adults. Twelve patients, ranging in age from 16 to 63 years, with metastatic colorectal or appendiceal carcinoma were studied by means of radioimmunoscintigraphy after injection of 5-10 mCi (185-370 MBq) of iodine-131-labeled B72.3 immunoglobulin G (IgG). Eight of the 12 patients had positive scans. In three of these patients the MoAb scan depicted tumors that were not found by other means. Positive scans had excellent correlation with surgical findings in seven patients and caused underestimation of the extent of disease in one patient. In one patient the scan was technically inadequate and could not be evaluated. In three patients the scan was negative. No adverse reactions were associated with the infusions.
- Research Organization:
- National Cancer Institute, Bethesda, MD (USA)
- OSTI ID:
- 5237959
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 167:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
FEMALE GENITALS
GASTROINTESTINAL TRACT
GONADS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
INTRAPERITONEAL INJECTION
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLING
LARGE INTESTINE
MEMBRANES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
PATIENTS
PERITONEUM
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RECTUM
SCINTISCANNING
SEROUS MEMBRANES
USES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
FEMALE GENITALS
GASTROINTESTINAL TRACT
GONADS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
INTRAPERITONEAL INJECTION
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLING
LARGE INTESTINE
MEMBRANES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
PATIENTS
PERITONEUM
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RECTUM
SCINTISCANNING
SEROUS MEMBRANES
USES