Estimates of dose to intraperitoneal micrometastases from alpha and beta emitters in radioimmunotherapy

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(90)90095-3· OSTI ID:6069113

Rotmensch, J; Roeske, J; Chen, G; Pelizzari, C; Montag, A; Weichselbaum, R; Herbst, A L ^[1]

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1. Univ. of Chicago, IL (USA)

Intraperitoneal metastases from ovarian and other gynecologic tumors are a significant source of treatment failure. In recent years, investigators have used radiolabeled monoclonal antibodies to treat this disease with encouraging results. We have developed a dose calculational technique which generates isodose distributions from intraperitoneally administered alpha and beta particle emitters. In this study we apply the calculations to tissue biopsy samples to determine the adequacy of dose to ovarian micrometastases. Tissue samples from staging biopsies at the time of surgical debulking are scanned to identify small metastases. The patient population studied comprised those with ovarian disease who based on clinical criteria would be considered good candidates for intraperitoneal radioimmunotherapy. The regions of interest (which include the tumor and surface of the peritoneum) are digitized and tumor volumes are contoured. Dose calculations based on the modeling of intraperitoneally administered antibodies radiolabeled with various isotopes is performed and the minimum dose to tumor and normal tissue is assessed. For example, with tumor uptake of 0.1% injected dose per gram of tissue, the surface tumor dose from alpha emitters is up to 45,000 rads. The dose falls to 6000 rads at approximately 40 microns from the peritoneal surface. The surface dose from 20 mCi 90Y administered in 1500 ml saline is up to 10,000 rads, and at a 2-mm depth, approximately 2000 rads. From our calculation dose distribution from radioimmunotherapy varies as a function of physical characteristics of the isotope, absorption of activity, and amount of disease being treated.

• OSTI ID: 6069113
• Journal Information: Gynecologic Oncology; (USA), Journal Name: Gynecologic Oncology; (USA) Vol. 38:3; ISSN GYNOA; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BODY
DOSES
FEMALE GENITALS
GONADS
IMMUNOLOGY
IMMUNOTHERAPY
MEDICINE
MEMBRANES
METASTASES
MONOCLONAL ANTIBODIES
NUCLEAR MEDICINE
ORGANS
OVARIES
PATIENTS
PERITONEUM
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOLOGY
RADIOTHERAPY
SEROUS MEMBRANES
THERAPY