Synthesis of (/sup 3/H)- and -(/sup 14/C)-labeled sulprostone

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · Prostaglandins; (United States)

OSTI ID:6256574

Schaaf, T K; Plattner, J J; Bussolotti, D L

The synthesis of N-methanesulfonyl 16-phenoxy-omega-tetranor PGE2 carboxamide (sulprostone--CP-34,089/ZK-57,671) labeled with tritium and carbon-14 is described. Sulprostone labeled with tritium in the phenoxy moiety by means of catalytic hydrogenolysis was obtained in a 17% radiochemical yield with a specific activity of 1.0 Ci/mmol. The methanesulfonamide-/sup 14/C derivative of sulprostone was prepared from methyl-/sup 14/C iodide in an 11.8% radiochemical yield having a specific activity of 18.8 mCi/mmol.

• Research Organization: Central Research, Pfizer Inc., Groton, Connecticut
• OSTI ID: 6256574
• Journal Information: Prostaglandins; (United States), Journal Name: Prostaglandins; (United States) Vol. 24:3; ISSN PRGLB
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550201 -- Biochemistry-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBON 14 COMPOUNDS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
DIAGNOSTIC USES
DRUGS
LABELLED COMPOUNDS
LABELLING
PROSTAGLANDINS
RADIOPHARMACEUTICALS
SYNTHESIS
TRITIUM COMPOUNDS
USES
YIELDS