Induction of osteosarcomas in mouse lumbar vertebrae by repeated external beta-irradiation

Journal Article · Tue Mar 14 23:00:00 EST 1989 · Cancer Res.; (United States)

OSTI ID:6252837

Ootsuyama, A; Tanooka, H

Besides skin tumors, osteosarcomas were induced at high frequency in the lumbar vertebrae of ICR mice by repeated local external irradiation of the back with /sup 90/Sr-/sup 90/Y beta-rays when irradiation was repeated three times a week until tumors appeared. The optimum dose range for osteosarcoma induction was 250-350 cGy per exposure at the surface of the back, or 125-175 cGy at the depth of the center of the bone. With the same irradiation schedule, the optimal dose of radiation for induction of osteosarcomas was much lower than that for induction of skin tumors.

• Research Organization: National Cancer Center Research Institute, Tokyo (Japan)
• OSTI ID: 6252837
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 49:6; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EVEN-EVEN NUCLEI
FRACTIONATED IRRADIATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANS
OSTEOSARCOMAS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
SKELETON
SKIN
STRONTIUM 90
STRONTIUM ISOTOPES
VERTEBRAE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
YTTRIUM 90
YTTRIUM ISOTOPES