Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Threshold-like dose of local beta irradiation repeated throughout the life span of mice for induction of skin and bone tumors

Journal Article · · Radiation Research; (USA)
DOI:https://doi.org/10.2307/3577987· OSTI ID:6143993
;  [1]
  1. National Cancer Center Research Institute, Tokyo (Japan)
+ Show Author Affiliations
The backs of female ICR mice were irradiated with beta rays from 90Sr-90Y three times a week throughout life. Previously we observed 100% tumor incidence at five different dose levels ranging from 1.5 to 11.8 Gy per exposure, but no tumor on repeated irradiation with 1.35 Gy for 300 days. In the present study, delay of tumor development was again seen at a dose of 1.5 Gy per exposure, with further delay at 1.0 Gy. The final tumor incidence was 100% with these two doses. At 0.75 Gy per exposure, no tumor appeared within 790 days after the start of irradiation, but one osteosarcoma and one squamous cell carcinoma did finally appear. These findings indicate a threshold-like response of tumor induction in this repeated irradiation system and further suggest that the apparent threshold may be somewhat less than 0.75 Gy per exposure.
OSTI ID:
6143993
Journal Information:
Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 125:1; ISSN 0033-7587; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Induction of osteosarcomas in mouse lumbar vertebrae by repeated external beta-irradiation
Journal Article · Tue Mar 14 23:00:00 EST 1989 · Cancer Res.; (United States) · OSTI ID:6252837
The TCD[sub 50] and regrowth delay assay in human tumor xenografts: Differences and implications
Journal Article · Thu Jan 14 23:00:00 EST 1993 · International Journal of Radiation Oncology, Biology and Physics; (United States) · OSTI ID:6876272
Biological effectiveness of fast neutrons on a murine osteosarcoma
Journal Article · Tue Feb 28 23:00:00 EST 1989 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:6277775

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
EVEN-EVEN NUCLEI
FRACTIONATED IRRADIATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANS
OSTEOSARCOMAS
RADIATION DOSES
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
SKIN
STRONTIUM 90
STRONTIUM ISOTOPES
THRESHOLD DOSE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
YTTRIUM 90
YTTRIUM ISOTOPES