N-isopropyl-p-( sup 123 I)iodoamphetamine SPECT in MELAS syndrome: Comparison with CT and MR imaging
- Univ. of Tsukuba (Japan)
Regional cerebral perfusion was studied in three patients with the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome, using single photon emission computed tomography (SPECT) with N-isopropyl-p-(123I)iodoamphetamine (IMP). Accumulation of the tracer was relatively decreased in the parietooccipital regions and also in the frontotemporal regions after stroke-like episodes. However, quantitative regional cerebral blood flow (rCBF) measurement showed that rCBF was relatively well preserved even at these sites, and a hyperemic state was observed at the sites of normal accumulation. IMP SPECT may be useful in the diagnosis and assessment of the progress of the MELAS syndrome.
- OSTI ID:
- 6248031
- Journal Information:
- Journal of Computer Assisted Tomography; (USA), Journal Name: Journal of Computer Assisted Tomography; (USA) Vol. 15:1; ISSN 0363-8715; ISSN JCATD
- Country of Publication:
- United States
- Language:
- English
Similar Records
SPECT with N-isopropyl-p iodoamphetamine in occlusive cerebrovascular diseases
Cerebral blood flow studies using N-isopropyl I-123 p-iodoamphetamine
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CEREBRAL CORTEX
CEREBRUM
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LACTIC ACID
MITOCHONDRIA
NERVOUS SYSTEM
NMR IMAGING
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PATIENTS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYMPATHOMIMETICS
TOMOGRAPHY
VASCULAR DISEASES