Regional distribution of N-isopropyl-p-(I-123)iodoamphetamine in cerebrovascular disease compared with regional cerebral blood flow and oxygen metabolism
N-isopropyl-p-(I-123)iodoamphetamine (IMP) has been introduced for the assessment of regional cerebral blood flow (RCBF) by single photon emission computed tomography (SPECT). Although some preliminary studies in animals have revealed a good correlation between the distribution of IMP and RCBF, it has not been validated in diseased states in humans. The purpose of this study is to compare the regional distribution of IMP measured by SPECT WITH RCBF and oxygen metabolism measured by positron emission tomography (PET). Twenty patients with cerebrovascular disease were studied. Following the intravenous IMP (3 mCi), SPECT was performed using a rotating gamma camera. PET study was carried out by continuous inhalation of 0-15 labeled gases to measure RCBF, oxygen extraction fraction (OEF) and oxygen utilization (CMR02). PET study and X-ray CT scan were performed on the same day, and SPECT with IMP was studied within a few days. In chronic cerebrovascular disease, the distribution of IMP was well correlated with RCBF. However, in two cases with cerebral infarction in the subacute stage, the discrepancy between IMP distribution and RCBF were observed. In these cases, relatively increased RCBF was demonstrated in the infarcted area where CMR02 was markedly depressed, and the distribution of IMP was more similar to that of CMR02. These results suggest that although SPECT with IMP is a valuable diagnostic tool for the assessment of cerebrovascular disease, IMP distribution may not be determined only by RCBF.
- Research Organization:
- Kyoto Univ. School of Medicine, Kyoto
- OSTI ID:
- 6794498
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
SPECT with N-isopropyl-p iodoamphetamine in occlusive cerebrovascular diseases
Quantifying regional cerebral blood flow by N-isopropyl-P-[I-123]iodoamphetamine (IMP) using a ring type single-photon emission computed tomography system
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
ANOXIA
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CEREBRAL ARTERIES
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISCHEMIA
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METABOLISM
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXYGEN 15
OXYGEN ISOTOPES
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TOMOGRAPHY
UPTAKE
VASCULAR DISEASES