Vinpocetine prevent ischemic cell damage in rat hippocampus
Journal Article
·
· Life Sci.; (United States)
The effects of vinpocetine on hippocampal cell damage and local cerebral blood flow (LCBF) were measured in a rat model of forebrain ischemia. Duration of ischemia was 10 min. LCBF was determined after 2 min of recirculation using the /sup 14/C-iodoantipyrine technique. Hippocampal cell loss was quantified histologically 7 days post-ischemia. Intraperitoneal application of vinpocetine 15 min prior to ischemia significantly reduced neuronal cell loss in hippocampal CA 1 sector from 60% to 28%. The drug led to a marked increase in blood flow in cortical areas, whereas LCBF remained unchanged in hippocampus and all other structures measured. It is suggested that the protective effect of vinpocetine does not depend on increased postischemic blood flow.
- Research Organization:
- Philipps-Universitaet, Marburg (Germany, F.R.)
- OSTI ID:
- 6244664
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 43:21; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BLOOD FLOW
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DISEASES
ESTERS
HIPPOCAMPUS
ISCHEMIA
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BLOOD FLOW
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DISEASES
ESTERS
HIPPOCAMPUS
ISCHEMIA
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES