Role of local neurons in cerebrocortical vasodilation elicited from cerebellum

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · Am. J. Physiol.: Heart Circ. Physiol.; (United States)

OSTI ID:6145721

Iadecola, C; Arneric, S P; Baker, H D; Tucker, L W; Reis, D J

The vasodilation elicited in cerebral cortex by stimulation of the cerebellar fastigial nucleus (FN) is mediated by input pathways coming from the basal forebrain. The authors studied whether these pathways mediate the cortical vasodilation via a direct action on local blood vessels or via interposed local neurons. Neurons were destroyed in the primary sensory cortex by local microinjection of the excitotoxin ibotenic acid (IBO). Five days later rats were anesthetized, paralyzed, and ventilated. Arterial pressure and blood gases were controlled, and FN was stimulated electrically. Local cerebral blood flow (LCBF) was measured using the (/sup 14/C)iodoantipyrine technique with autoradiography. Five days after IBO, neurons were destroyed in a restricted cortical area, and afferent fibers and terminals were preserved. The selectivity of the neuronal loss was established by histological and biochemical criteria and by transport of horseradish, peroxidase from or into the lesion. Within the lesion, resting LCBF was unaffected, but the increase in LCBF evoked from the FN was abolished. In contrast the vasodilation elicited by hypercapnia was preserved. In the rest of the brain the vasodilation elicited from FN was largely unaffected. The authors conclude that the vasodilation evoked from FN in cerebral cortex depends on the integrity of a restricted population of local neurons that interact with the local microvasculature.

• Research Organization: Cornell Univ. Medical College, New York, NY (USA)
• OSTI ID: 6145721
• Journal Information: Am. J. Physiol.: Heart Circ. Physiol.; (United States), Journal Name: Am. J. Physiol.: Heart Circ. Physiol.; (United States) Vol. 21:6; ISSN AJPPD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
AUTORADIOGRAPHY
BIOCHEMISTRY
BLOOD CHEMISTRY
BLOOD FLOW
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBON-CARBON LYASES
CARBOXY-LYASES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CYTOCHEMISTRY
DECARBOXYLASES
ENZYME ACTIVITY
ENZYMES
LABELLED COMPOUNDS
LYASES
NERVE CELLS
NERVOUS SYSTEM
ORGANS
PHYSIOLOGY
SOMATIC CELLS
TRANSFERASES
VASODILATION