Neuronal damage and calcium accumulation following transient cerebral ischemia in the rat

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Molecular and Chemical Neuropathology; (USA)

DOI:https://doi.org/10.1007/BF03159945· OSTI ID:5474007

Araki, T; Inoue, T; Kato, H; Kogure, K; Murakami, M ^[1]

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1. Tohoku Univ. School of Medicine, Sendai, (Japan)

The purpose of this study was to examine the distribution of neuronal damage following transient cerebral ischemia in the rat model of four-vessel occlusion utilizing light microscopy as well as {sup 45}Ca-autoradiography. Transient ischemia was induced for 30 min. The animals were allowed to survive for 7 d after ischemia. In the animals subjected to ischemia, the most frequently and seriously damaged areas were the paramedian region of hippocampus, the hippocampal CA1 sector, and the dorsolateral part of striatum, followed by the inferior colliculus, the substantia nigra, the frontal cortex, and the thalamus, which were moderate damaged. Furthermore, the cerebellar Purkinje neurons, the hippocampal CA4 sector, the medial geniculate body, and the hippocampal CA3 sector were slightly affected. {sup 45}Ca-autoradiographyic study also revealed calcium accumulation in the identical sites of ischemic neuronal damage, except for the frontal cortex. Regional cerebral blood flow during 10 min of ischemia was severely decreased in selectively vulnerable areas. The blood flow in the medial geniculate body, the substantia nigra, the inferior colliculus, and the cerebellum was less pronounced than that in the selectively vulnerable areas. The present study demonstrates that transient cerebral ischemia can produce significant neuronal damage not only in the selectively vulnerable regions, but also in the brainstem.

• OSTI ID: 5474007
• Journal Information: Molecular and Chemical Neuropathology; (USA), Journal Name: Molecular and Chemical Neuropathology; (USA) Vol. 12:3; ISSN 1044-7393; ISSN MCHNE
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANEMIAS
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BLOOD FLOW
BODY
BRAIN
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
HEMIC DISEASES
INJURIES
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOTOPES
MAMMALS
METALS
NERVES
NERVOUS SYSTEM
NUCLEI
ORGANS
PATHOGENESIS
RADIOISOTOPES
RATS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES