Evidence for a compartmentation of brain microsomal diacylglycerol
Journal Article
·
· J. Lipid Res.; (United States)
OSTI ID:6240635
Phosphatidylcholine synthesis from CDP-(methyl-/sup 14/C)choline and membrane-bound diacyl-(U-/sup 14/C)-sn-glycerol, formed through the glycerol phosphate pathway, has been examined in vitro in rat brain microsomes. When labeled diacylglycerol was incubated in the presence of unlabeled CDP-choline, the rate of phospholipid labeling looked very different from that measured in incubations of unlabeled diacylglycerol with CDP-(methyl-/sup 14/C)choline. Evidence is given that diacylglycerol formed through the glycerol phosphate pathway belongs to a metabolic pool separate from the bulk membrane diacylglycerol.
- Research Organization:
- Institute of Biological Chemistry, The Medical School, University of Perugia, Italy
- OSTI ID:
- 6240635
- Journal Information:
- J. Lipid Res.; (United States), Journal Name: J. Lipid Res.; (United States) Vol. 23:7; ISSN JLPRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BODY
BRAIN
CARBON 14 COMPOUNDS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CEPHALINS
CHOLINE
DRUGS
ESTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIPIDS
LIPOTROPIC FACTORS
MAMMALS
METABOLISM
MICROSOMES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHOLIPIDS
QUATERNARY COMPOUNDS
RATS
REACTION KINETICS
RODENTS
SYNTHESIS
VERTEBRATES
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BODY
BRAIN
CARBON 14 COMPOUNDS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CEPHALINS
CHOLINE
DRUGS
ESTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIPIDS
LIPOTROPIC FACTORS
MAMMALS
METABOLISM
MICROSOMES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHOLIPIDS
QUATERNARY COMPOUNDS
RATS
REACTION KINETICS
RODENTS
SYNTHESIS
VERTEBRATES