Evaluation of the potential carcinogenicity of gamma-hexachlorocyclohexane (lindane). Final report

Technical Report · Wed Jun 01 04:00:00 EDT 1988

OSTI ID:6238070

Gamma-Hexachlorocyclohexane (gamma-BHC or Lindane) is a probable to possible human carcinogen, classified as weight-of-evidence Group B2/C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient to Limited, and the evidence from human studies is Inadequate. The potency factor (F) for gamma-BHC is estimated to be 7.39/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, gamma-BHC is assigned a MEDIUM hazard ranking for the purposes of RQ adjustment. (When the weight-of-evidence is expressed as a range, the hazard ranking is based on the higher weight-of-evidence group.)

• Research Organization: Syracuse Research Corp., NY (United States)
• OSTI ID: 6238070
• Report Number(s): PB-93-185064/XAB; CNN: EPA-68-03-3112; EPA-68-03-3182
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
ANIMALS
AROMATICS
BENZENE
CARCINOGENS
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INSECTICIDES
LINDANE
NATIONAL ORGANIZATIONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PESTICIDES
POPULATIONS
PROCESSING
REGULATORY GUIDES
RISK ASSESSMENT
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US ORGANIZATIONS
WEIGHT