Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid

Journal Article · Tue Jan 01 00:00:00 EST 1980 · J. Biol. Chem.; (United States)

OSTI ID:6231033

Wykle, R L; Malone, B; Snyder, F

1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine, derived chemically from choline plasmalogens of beef heart, has been shown to possess powerful antihypertensive activity and to be an extremely potent platelet-activating factor. In the present study, microsomal preparations of rat spleen were shown to synthesize 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine by an acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase reaction; the acetyltransferase appears to be different from the acyltransferase responsible for the transfer of palmitate to glycerolipids.

• Research Organization: Oak Ridge Associated Universities, TN
• DOE Contract Number: AC05-760R00033
• OSTI ID: 6231033
• Journal Information: J. Biol. Chem.; (United States), Vol. 255:21
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LIPIDS
BIOSYNTHESIS
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOLOGICAL PATHWAYS
BLOOD PLATELETS
CARBON 14 COMPOUNDS
CHOLINE
EDTA
EGTA
ENZYME ACTIVITY
HYPERTENSION
INHIBITION
RADIOCHROMATOGRAPHY
RATS
SPLEEN
ALCOHOLS
AMINES
AMINO ACIDS
AMMONIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHELATING AGENTS
CHEMISTRY
CHROMATOGRAPHY
DISEASES
DRUGS
GLYCOLS
HYDROXY COMPOUNDS
KINETICS
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
QUATERNARY COMPOUNDS
REACTION KINETICS
RODENTS
SEPARATION PROCESSES
SYMPTOMS
SYNTHESIS
VASCULAR DISEASES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550501 - Metabolism- Tracer Techniques