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In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid

Journal Article · · Life Sci.; (United States)
; ; ;
This report describes the in vivo metabolism of a new class of naturally occurring biologically active phospholipids (1-alkyl-2-acetyl-sn-glycero-3-phosphocholines) that can cause hypotension and platelet aggregation. After intravenous injection in male rats, the acetylated ether phospholipid (1-(1',2'-/sup 3/H)alkyl) is rapidly cleared (T/sub 1/2/ approx. = 30 s) from blood and its metabolites are found in a variety of tissues. The tissues containing the highest levels of radioactivity are lung, liver, spleen, and kidney. Chromatographic results showed that a considerable portion of the active lipid is not readily catabolized in some of the major tissues examined; however, inactive metabolites were also found, mainly 1-alkyl-2-lyso-sn-glycero-3-phosphocholine and 1-alkyl-2-acyl-sn-glycero-3-phosphocholine; the latter has a long chain fatty acid at the sn-2 position instead of the acetate. The findings are consistent with our earlier data that show these same tissues have the most active enzyme systems for metabolizng 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine.
Research Organization:
Oak Ridge Associated Universities, TN
DOE Contract Number:
AC05-76OR00033
OSTI ID:
6230919
Journal Information:
Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 29:8; ISSN LIFSA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DISTRIBUTION
ENZYME ACTIVITY
ESTERS
GLANDS
HYPOTENSION
IN VIVO
KIDNEYS
LABELLED COMPOUNDS
LIPIDS
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
QUANTITATIVE CHEMICAL ANALYSIS
RATS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
SPLEEN
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
VERTEBRATES