Decreased uv mutagenesis in cdc8, a DNA replication mutant of Saccharomyces cerevisiae
A DNA replication mutant of yeast, cdc8, was found to decrease uv-induced reversion of lys2-1, arg4-17, tryl and ural. This effect was observed with all three alleles of cdc8 tested. Survival curves obtained following uv irradiation in cdc8 rad double mutants show that cdc8 is epistatic to rad6, as well as to rad1; cdc8 rad51 double mutants seem to be more sensitive than the single mutants. Since uv-induced reversion in cdc8 rad1 and cdc8 rad51 double mutants is like that of the cdc8 single mutants, we conclude that CDC8 plays a direct role in error-prone repair. To test whether CDC8 codes for a DNA polymerase, we have purified both DNA polymerase I and DNA polymerase II from cdc8 and CDC+ cells. The purified DNA polymerases from cdc8 were no more heat labile than those from CDC+, suggesting that CDC8 is not a structural gene for either enzyme.
- Research Organization:
- Rochester Univ., NY (USA)
- DOE Contract Number:
- EY-76-C-02-3490
- OSTI ID:
- 6230263
- Report Number(s):
- UR-3490-1570
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400 -- Genetics
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DATA
DATA FORMS
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FUNGI
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GRAPHS
INFORMATION
IRRADIATION
MICROORGANISMS
MUTAGENESIS
MUTANTS
NUCLEIC ACID REPLICATION
NUMERICAL DATA
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RECOVERY
REPAIR
REVERTANTS
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
ULTRAVIOLET RADIATION
YEASTS
550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DATA
DATA FORMS
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FUNGI
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GRAPHS
INFORMATION
IRRADIATION
MICROORGANISMS
MUTAGENESIS
MUTANTS
NUCLEIC ACID REPLICATION
NUMERICAL DATA
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RECOVERY
REPAIR
REVERTANTS
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
ULTRAVIOLET RADIATION
YEASTS