Effects of brief and intermediate exposures to sulfate submicron aerosols and sulfate injections on cardiopulmonary function of dogs and tracheal mucous velocity of sheep

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530038· OSTI ID:6228754

Sackner, M A ^[1]; Dougherty, R L; Chapman, G A; Cipley, J; Perez, D; Kwoka, M; Reinhart, M; Brito, M; Schreck, R

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1. Mount Sinai Medical Center, Miami Beach, FL

Pulmonary mechanics of anesthetized dogs were not changed or were minimally altered by breathing the following compounds as submicron aerosols in concentrations up to 17.3 mg/m/sup 3/ for 7.5 min: (1) sodium chloride (as a control), (2) sodium sulfate, (3) ammonium sulfate, (4) zinc sulfate, (5) zinc ammonium sulfate, (6) ammonium bisulfate, (7) aluminum sulfate, (8) manganese sulfate, (9) nickel sulfate, (10) copper sulfate, (11) ferrous fulfate, and (12) ferric sulfate. Submicron aerosols of these compounds in concentrations of 4.1 to 8.8 mg/m/sup 3/, administered for 4 h to anesthetized dogs, did not affect mechanics of breathing, hemodynamics, and arterial blood gases. In conscious sheep, tracheal mucous velocity was not altered by exposure to the submicron aerosols of the sulfate compounds. None of these compounds, injected iv in a dose of 1 mg, had adverse effects on mechanics of breathing, pulmonary and systemic hemodynamics, or arterial blood gases. In 100-mg injections, zinc sulfate and zinc ammonium sulfate produced a fall in cardiac output, systemic hypotension, hypoxemia, and metabolic acidosis. Copper sulfate at this dose produced pulmonary hypertension, a fall in cardiac output, hypoxemia, respiratory acidosis, and a decrease of specific total respiratory conductance. It is concluded that submicron aerosols of sulfate salts do not have adverse cardiopulmonary effects when administered in high concentrations for up to 4 h. However, prolonged exposure to high concentrations of zinc sulfate, zinc ammonium sulfate, and copper sulfate aerosols might have adverse cardiopulmonary effects.

• OSTI ID: 6228754
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 7:6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALKALI METAL COMPOUNDS
AMMONIUM COMPOUNDS
AMMONIUM SULFATES
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COLLOIDS
COPPER COMPOUNDS
COPPER SULFATES
DATA
DISEASES
DISPERSIONS
DOGS
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
HYPERTENSION
INFORMATION
INHALATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
IRON COMPOUNDS
IRON SULFATES
MAMMALS
MANGANESE COMPOUNDS
MANGANESE SULFATES
NICKEL COMPOUNDS
NICKEL SULFATES
NUMERICAL DATA
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SODIUM COMPOUNDS
SODIUM SULFATES
SOLS
SULFATES
SULFUR COMPOUNDS
SYMPTOMS
TRACHEA
TRANSITION ELEMENT COMPOUNDS
VASCULAR DISEASES
VERTEBRATES
ZINC COMPOUNDS
ZINC SULFATES