Effects of sodium nitrate aerosol on cardiopulmonary function of dogs, sheep, and man
Submicronic aerosols of nitrate salts are synthesized in the atmosphere through further oxidation of nitrogen oxides produced during the burning of fossil fuels. This study was conducted to determine whether brief exposure to submicronic aerosol of sodium nitrate in high concentrations adversely affects the cardiopulmonary system. In all studies, submicronic aerosol of sodium chloride was used as a control. Anesthetized dogs breathing up to 10 mg/m/sup 3/ of sodium nitrate (NaNO/sub 3/) aerosol for 7.5 min showed no significant alterations in respiratory resistance, static lung compliance, and functional residual capacity. A 4-h exposure to NaNO/sub 3/ aerosol (5 mg/m/sup 3/) produced neither significant changes in lung mechanics, functional residual capacity, pulmonary and systemic arterial pressures, cardiac output, heart rate, and arterial blood gases in anesthetized dogs nor a change in tracheal mucous velocity in conscious sheep. Both normal and asthmatic adults who breathed submicronic aerosol of NaNO/sub 3/ (up to 1 mg/m/sup 3/) for 10 min showed no significant changes in lung volumes, distribution of ventilation, ear oximetry, dynamic mechanics of breathing, and oscillation mechanics of the chest-lung system. NaNO/sub 3/ aerosol (1000 ..mu..g/m/sup 3/) for 10 min did not significantly change pulmonary capillary blood flow, diffusing capacity, oxygen consumption, and pulmonary tissue volume as measured by a rebreathingtechnique. Thus, brief exposure to high concentrations of submicronic aerosol of sodium nitrate does not produce immediate adverse effects on cardiopulmonary function of anesthetized dogs, conscious sheep, and normal and asthmatic adults.
- Research Organization:
- Mount Sinai Medical Center, Miami Beach, FL
- OSTI ID:
- 5456632
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 18:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DISPERSIONS
DOGS
DOMESTIC ANIMALS
DYNAMIC FUNCTION STUDIES
ENERGY SOURCES
FOSSIL FUELS
FUELS
HALIDES
HALOGEN COMPOUNDS
HEART
INHALATION
INJECTION
INTAKE
LUNGS
MAMMALS
MAN
NITRATES
NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PARTICLE SIZE
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SIZE
SODIUM CHLORIDES
SODIUM COMPOUNDS
SODIUM NITRATES
SOLS
TOXICITY
VERTEBRATES