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Defective transient endogenous spleen colony formation in S1/S1/sup d/ mice. [Gamma radiation]

Journal Article · · J. Cell. Physiol.; (United States)
 [1]; ; ; ;
  1. Military School of Medicine, Warsaw, Poland
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WCB6F/sub 1/ mice of the genotype S1/S1/sup d/ did not form transient 5-day endogenous spleen colonies following midlethal irradiation, either spontaneously or in response to postirradiation bleeding. Their hematologically normal (+/+) littermates produced colonies equivalent in number and morphologic type to a normal strain (D2B6F/sub 1/), as evaluated by both macroscopic and microscopic criteria. Bone marrow cells from S1/S1/sup d/ mice, when transplanted into lethally irradiated +/+ mice, were able to generate equivalent numbers of transient endogenous spleen colonies (TE-CFUs), as compared to that obtained when syngeneic +/+ marrow cells were injected into lethally irradiated +/+ recipients. A defective growth of an early class of hematopoietic progenitor cells, resulting in the clinical course of the S1/S1/sup d/ anemia is suggested and confirms previous reports on the microenvironmental nature of this abnormality.

OSTI ID:
6227783
Journal Information:
J. Cell. Physiol.; (United States), Journal Name: J. Cell. Physiol.; (United States) Vol. 99:1; ISSN JCLLA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW CELLS
CFU
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
GENOTYPE
HEMATOLOGY
HEMIC DISEASES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LETHAL IRRADIATION
MAMMALS
MEDICINE
MICE
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN
SYMPTOMS
TRANSPLANTS
VERTEBRATES