Glucose metabolism in mice during and after whole-body hyperthermia
Journal Article
·
· NIDA Res. Monogr.; (United States)
OSTI ID:6225150
Researchers studied glucose turnover in male inbred mice during and after whole-body hyperthermia for 1 hour at 40 degrees or 41 degrees C by giving them injections of (/sup 14/C)glucose with and without a glucose load and measuring the expired /sup 14/Co/sub 2/. Expiration of /sup 14/CO/sub 2/ was increased during hyperthermia but decreased considerably afterward. The latter effect was enhanced by a glucose load. This inhibition depended on the glucose concentration. Metabolic studies showed a depletion of several glycolytic metabolites, especially glycogen and lactate, after whole-body hyperthermia. Combined treatment of hyperthermia and a glucose injection 1 hour later led to an increased level of glucose 6-phosphate, which indicated a block in glycolysis between glucose 6-phosphate and fructose 1,6-diphosphate. This inhibition did not occur when glucose was given before the hyperthermia treatment. Lactate accumulation was not observed under any conditions.
- Research Organization:
- Institut fuer Medizinische Strahlenphysik und Strahlenbiologie, Universitaetsklinikum Essen, Federal Republic of Germany
- OSTI ID:
- 6225150
- Journal Information:
- NIDA Res. Monogr.; (United States), Journal Name: NIDA Res. Monogr.; (United States) Vol. 61; ISSN MIDAD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
560201 -- Thermal Effects-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY TEMPERATURE
CARBOHYDRATES
CARBON 14
CARBON ISOTOPES
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
DECOMPOSITION
EVEN-EVEN NUCLEI
GLUCOSE
GLYCOLYSIS
HEXOSES
HYPERTHERMIA
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEASURING METHODS
METABOLISM
MICE
MONOSACCHARIDES
NORTH AMERICA
NUCLEI
ORGANIC COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOISOTOPES
RODENTS
SACCHARIDES
SENSITIVITY
TEMPERATURE EFFECTS
TRACER TECHNIQUES
USA
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560201 -- Thermal Effects-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY TEMPERATURE
CARBOHYDRATES
CARBON 14
CARBON ISOTOPES
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
DECOMPOSITION
EVEN-EVEN NUCLEI
GLUCOSE
GLYCOLYSIS
HEXOSES
HYPERTHERMIA
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEASURING METHODS
METABOLISM
MICE
MONOSACCHARIDES
NORTH AMERICA
NUCLEI
ORGANIC COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOISOTOPES
RODENTS
SACCHARIDES
SENSITIVITY
TEMPERATURE EFFECTS
TRACER TECHNIQUES
USA
VERTEBRATES
YEARS LIVING RADIOISOTOPES