Osteogenetic activity in composite grafts of demineralized compact bone and marrow

Journal Article · Tue Mar 01 04:00:00 EST 1983 · Clin. Orthop.; (United States)

DOI:https://doi.org/10.1097/00003086-198303000-00032· OSTI ID:6224923

Wittbjer, J; Palmer, B; Rohlin, M; Thorngren, K G

The effects of a composite graft of autologous marrow and demineralized autologous compact bone on the healing of a surgically created bone defect were observed in adult rabbits. A segment of the radius was bilaterally resected, demineralized, and replaced. On one side the bone graft was supplemented with autologous marrow. The new bone formation was measured 14 and 28 days after operation by roentgenography, including planimetry with scintigraphy and autoradiography using /sup 99m/Tc-labelled MDP. The composite graft, i.e., demineralized compact bone and marrow, had a significantly higher (p less than 0.01) bone formation rate 14 days after operation compared with the graft with demineralized compact bone in the opposite radius. At 28 days, however, there were no differences between the sides. Viable autologous marrow cells and demineralized autologous compact bone graft accelerate the rate of osteogenesis, but only at the beginning of the healing process.

• Research Organization: Maxillofacial Center, Malmoe General Hospital, Sweden
• OSTI ID: 6224923
• Journal Information: Clin. Orthop.; (United States), Journal Name: Clin. Orthop.; (United States) Vol. 173; ISSN CORPA
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BIOMEDICAL RADIOGRAPHY
BODY
BONE MARROW
BONE TISSUES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
GRAFTS
HEALING
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RECOVERY
SCINTISCANNING
SKELETAL DISEASES
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES