The Clinical Application of Bone Marrow Grafting
Eight patients. were treated with total thoracic irradiation of 2500 to 3058 r and subsequently received intravenous infusions of stored autologous bone marrow. Sternal bone marrow recovery was somewhat increased by this procedure. One patient receiving trunk irradiation to a dose of 580 r recovered rapidly after autologous marrow infusion. One patient receiving total--body irradiation to a center dose of 300 to 350 r showed rapid recovery after autologous marrow infusion. In a study of nineteen patients treated with chemotherapeutic agents it was found that in those who had received large doses of mustine hydrochloride and mannomustine dihydrochloride, the rapidity of hematological recovery was increased, and a less marked benefit was noted in patients treated with Ndeacetylthiocolchicine and triethyleneglycol diglycidyl ether. In those cases treated with cyclophosphamide and phenylalanine mustard, no benefit from autologous marrow infusion was detected with the doses employed. Twentythree patients received homologous marrow infusions. Twelve showed subsequent improvement of the blood picture, but this was not due to successful bone marrow homografts. Successful, albeit transient, grafting occurred in one case. A second patient probably had a take, but she died before proof could be obtained. (auth)
- Research Organization:
- Westminster Hospital and Medical School, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-007821
- OSTI ID:
- 4755189
- Journal Information:
- British Journal of Cancer, Journal Name: British Journal of Cancer Journal Issue: 3 Vol. 16; ISSN 0007-0920
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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