Toxicological study of benzotrifuroxan

Technical Report · Fri Apr 01 00:00:00 EST 1983

OSTI ID:6217715

London, J E; Smith, D M

The calculated acute oral LD/sub 50//sup 30/ (lethal dose for 50% of the animals occurring within 30 days after compound administration) value for Benzotrifuroxan (BTF) was 2884 mg/kg body weight in rats. The acute oral LD/sub 50//sup 30/ value in mice was greater than 5 g/kg. According to classical guidelines, this compound would be considered slightly toxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. The eye irritation study demonstrated BTF to be highly irritant when in contact with the eye, even to the point of causing corneal opacification and blindness. The sensitization study in the guinea pig did not show BTF to be deleterious in this regard.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6217715
• Report Number(s): LA-9746-MS; ON: DE83013231
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOFURANS
LETHAL DOSES
TOXICITY
CHEMICAL EXPLOSIVES
EYES
INGESTION
SENSITIVITY
SKIN
BODY
BODY AREAS
DOSES
EXPLOSIVES
FACE
FURANS
HEAD
HETEROCYCLIC COMPOUNDS
INTAKE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
SENSE ORGANS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)