Reference dose (RfD): description and use in health risk assessments

Journal Article · Thu Dec 01 00:00:00 EST 1988 · Regul. Toxicol. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0273-2300(88)90047-5· OSTI ID:6211218

Barnes, D G; Dourson, M

For many years the concept of the acceptable daily intake has served the toxicological and regulatory fields quite well. However, as approaches to assessing the health significance of exposures to noncarcinogenic substances receive greater scrutiny, some difficulties with this traditional approach have become more apparent. Consequently, the concept of the reference dose is introduced in order to avoid use of prejudicial terms (e.g., safety and acceptable), to promote greater consistency in the assessment of noncarcinogenic chemicals, and to maintain the functional separation between risk assessment and risk management.

• Research Organization: nvironmental Protection Agency, Washington, DC (USA)
• OSTI ID: 6211218
• Journal Information: Regul. Toxicol. Pharmacol.; (United States), Vol. 8:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
XENOBIOTICS
HEALTH HAZARDS
CALIBRATION STANDARDS
DOSE-RESPONSE RELATIONSHIPS
RISK ASSESSMENT
HAZARDS
STANDARDS
560300* - Chemicals Metabolism & Toxicology