Assessing human risks posed by neurotoxic substances. Draft report (Final)

Technical Report · Fri Dec 16 04:00:00 EST 1988

OSTI ID:6808109

The risk assessment approaches outlined have been extensively discussed in various federal and state regulations and guidance documents as well as in the scientific literature. Until the present most of the discussion has been devoted to substances that are carcinogenic. Some basis has been found for development of explicit descriptions of carcinogenic risk, and most of the guidance documents mentioned deal with this issue. There is some discussion of noncarcinogenic effects in the NAS Drinking Water and Health series, in EPA's Toxic Substances Control Act Test Guidelines and in various documents issued by the World Health Organization. In most of these cases, and in many specific regulatory applications, the Acceptable Daily Intake approach to risk characterization (or its equivalent in occupational settings) is accepted.

• Research Organization: ENVIRON Corp., Washington, DC (USA)
• OSTI ID: 6808109
• Report Number(s): PB-90-209339/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
CARCINOGENS
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
MAMMALS
MAN
MATERIALS
NERVOUS SYSTEM
PRIMATES
PROGRESS REPORT
RISK ASSESSMENT
SENSITIVITY
TOXIC MATERIALS
TOXINS
VERTEBRATES