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Effects of lead and natriuretic hormone on kinetics of sodium-potassium-activated adenosine triphosphatase: possible relevance to hypertension

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.8878113· OSTI ID:6211027
; ;
Inhibition of vascular smooth muscle sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) has been postulated as a central mechanism in enhancing vascular contractility. In the present study, kinetics of inhibition of Na-K-ATPase by lead, ouabain, and natriuretic hormone (NH) was studied in a purified hog cerebral cortex enzyme preparation. Determination of I/sub 50/ values for lead, ouabain, and NH revealed that NH is the most potent inhibitor of the enzyme system. Kinetic analyses indicated that lead and NH exhibited different inhibitory mechanisms. The inhibition by lead was noncompetitive with respect to potassium and competitive with respect to sodium and MgATP. Natriuretic hormone was noncompetitive with respect to potassium, uncompetitive with respect to MgAPT, and exhibited no inhibitory effect with respect to sodium. Synergism between lead and NH in the inhibition of Na-K-ATPase raises the possibility that lead may be a contributory factor in hypertension via this mechanism.
Research Organization:
Univ. of California, Los Angeles (USA)
OSTI ID:
6211027
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 78; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ALKALI METAL COMPOUNDS
ANIMALS
ATP-ASE
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CATIONS
CHARGED PARTICLES
DISEASES
DOMESTIC ANIMALS
DRUGS
ENZYMES
GLYCOSIDES
HORMONES
HYDROLASES
HYPERTENSION
INHIBITION
IONS
KINETICS
LEAD COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
OUABAIN
PATHOGENESIS
PHOSPHOHYDROLASES
POTASSIUM COMPOUNDS
REACTION KINETICS
SODIUM COMPOUNDS
STROPHANTHINS
SWINE
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES