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Characteristics of a (Na/sup +/K/sup +/)-ATPase inhibitor in extracts of tea

Journal Article · · Am. J. Clin. Nutr.; (United States)
OSTI ID:6133528
;
Extracts of tea were examined for inhibitors of the sodium-potassium pump by investigating the effect of the extracts on 1) isolated preparations of (Na/sup +/-K/sup +/)-ATPase from hog brain and human blood cells; 2) the displacement of radioactive ouabain from its specific receptor on red blood cells, and 3) the uptake of radioactive rubidium in intact red blood cells. It has been found that extracts of tea were potent inhibitors of the purified hog brain (Na/sup +/-K/sup +/)-ATPase. However, the inhibition was not specific for the (Na/sup +/-K/sup +/)-ATPase and the extract of tea did not displace /sup 3/H-ouabain in a specific ouabain-receptor assay. Additionally, the tea extracts displayed only a small inhibitory effect on the uptake of /sup 86/Rb in intact red blood cells. These observations suggest that the material is not like digitalis and that, unlike cardiac glycosides, it may inhibit the activity of the (Na/sup +/-K/sup +/)-ATPase by interacting with the enzyme at intracellular sites.
Research Organization:
Charing Cross Hospital Medical School, London, England
OSTI ID:
6133528
Journal Information:
Am. J. Clin. Nutr.; (United States), Journal Name: Am. J. Clin. Nutr.; (United States) Vol. 40:1; ISSN AJCNA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACID ANHYDRASES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ATP-ASE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BRAIN
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATIONS
CENTRAL NERVOUS SYSTEM
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DRUGS
ENZYME INHIBITORS
ENZYMES
ERYTHROCYTES
GLYCOSIDES
HYDROLASES
INTERMEDIATE MASS NUCLEI
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OUABAIN
PHOSPHOHYDROLASES
PLANTS
POTASSIUM COMPOUNDS
RADIOISOTOPES
RECEPTORS
RUBIDIUM 86
RUBIDIUM ISOTOPES
SODIUM COMPOUNDS
STROPHANTHINS
TEA PLANTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS