Short-term radioprotective effects of WR-2721 on the rat parotid glands. [X radiation]
The radioprotective capacity of the chemoprotector WR-2721 was assessed in the rat parotid gland using gland weight and amylase content as the indicators of effect over the 9-day period following x irradiation with 1.6, 3.2, and 6.4 kR of acute x rays. The decline and recovery of weights and amylase content were measured and compared in animals which had and had not received WR-2721 just prior to irradiation. Analysis of the dose-response curves for the WR-2721 protected vs nonprotected animals yielded dose modification factors of 2.5 for gland weight, 1.7 for amylase concentration, and 1.8 for total gland amylase. Thus, WR-2721 was found to be effective in yet another tissue and to a degree consistent with that of other organs and systems.
- Research Organization:
- Temple Univ., Philadelphia, PA
- OSTI ID:
- 6202767
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
GLANDS
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SALIVARY GLANDS
VERTEBRATES
X RADIATION