Radioprotection of the rat parotid gland by WR-2721: morphology at 60 days post-irradiation

Journal Article · Tue Apr 01 04:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90056-5· OSTI ID:5098350

Pratt, N E; Sodicoff, M; Liss, J; Davis, M; Sinesi, M

The ultrastructure of rat parotid glands protected by S-2(3-aminopropylamino) ethyl phosphorothioate (WR-2721) was evaluate 60 days following a single dose of 3.2 kR of x-irradiation and compared with that of similarly irradiated but non-protected glands. Non-protected glands suffered a drastic reduction in the amount of acinar tissue while ducts and blood vessels exhibited only minor morphological changes. The evidence of acinar loss was provided by the presence of excessive and redundant basal laminae around surviving acini, and large condensations of empty basal laminal profiles in the spaces between surviving structures. The blood vessels present at 60 days post-irradiation showed no evidence of damage. However, there were additional layers of basal lamina around occasional capillaries, which others have interpreted as evidence of previous endothelial repair. The WR-2721 protected glands showed similar signs of damage but to a much lesser degree. Therefore, this paper shows that WR-2721 is effective in protecting the rat parotid gland, specifically the radiosensitive acinar cells.

• Research Organization: Temple Univ. School of Medicine, Philadelphia, PA
• OSTI ID: 5098350
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:4; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560100 -- Biomedical Sciences
Applied Studies-- Radiation Effects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
CHEMICAL ANALYSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
GLANDS
IONIZING RADIATIONS
IRRADIATION
LOCAL IRRADIATION
MAMMALS
MEDICINE
MICROSCOPY
MORPHOLOGICAL CHANGES
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOCHEMICAL ANALYSIS
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SALIVARY GLANDS
ULTRASTRUCTURAL CHANGES
VERTEBRATES
X RADIATION