Effect of dose rate on the induction of DNA double-strand breaks in eucaryotic cells

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575532· OSTI ID:6200083

Frankenberg-Schwager, M; Frankenberg, D; Bloecher, D; Adamczyk, C

Irradiation of diploid yeast cells with 30-MeV electrons at a high dose rate (130 Gy/min) was previously shown to yield a linear-quadratic function between irreparable double-strand breaks and dose. The quadratic term is reduced when irradiation is performed with /sup 60/Co ..gamma.. rays at a low dose rate (0.55 Gy/min). This effect of dose rate at the level of double-strand breaks correlates with that previously found at the level of colony-forming ability of yeast cells irradiated in the same dose range. By analogy with the results obtained in survival studies it is proposed that the linear component of the relationship between irreparable double-strand breaks and dose is due to a single track of an electron of medium energy, whereas the quadratic component is caused by the cooperative effect of track ends, each of which is produced by a separate traversal of a slow electron through the yeast nucleus.

• Research Organization: Gesellschaft fuer Strahlen-und Umweltforschung mbH, Frankfurt, Germany
• OSTI ID: 6200083
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 87:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COBALT 60
COBALT ISOTOPES
DNA
DOSE RATES
DOSES
ELECTROMAGNETIC RADIATION
FUNGI
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
MUTATIONS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PLANTS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RECOVERY
REPAIR
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
SPONTANEOUS MUTATIONS
STRAND BREAKS
SURVIVAL CURVES
TIME DEPENDENCE
YEARS LIVING RADIOISOTOPES
YEASTS