A kinetic analysis of the repair of radiation-induced DNA double-strand breaks
- Tamkang Univ., Taiwan (China)
The repair of radiation-induced DNA double-strand breaks (DSBs) is analyzed kinetically. It is assumed that a fraction of the damaged sites in the DNA duplex are irreparable. The kinetic model takes the effect of radiation dose into account. The analysis of the available experimental data reveals that, although the number of irreparable DSBs is a quadratic function of radiation dose, the normalized number of irreparable DSBs correlates linearly with this variable.
- OSTI ID:
- 6715294
- Journal Information:
- Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 122:3; ISSN 0033-7587; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
DNA REPAIR
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIOINDUCTION
RECOVERY
REPAIR
STRAND BREAKS
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
DNA REPAIR
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIOINDUCTION
RECOVERY
REPAIR
STRAND BREAKS