Cerebral perfusion imaging with iodine 123-labeled amines
Two amines, N-isopropyl p-iodoamphetamine and N,N,N'-trimethyl-N'-(2-hydroxyl-3-methyl-5-iodobenzyl)-1,3-prop anediamine, have been labeled with iodine 123. The brain uptake of these radioactive tracers is proportional to cerebral blood flow. These tracers are retained in the brain for a sufficiently long time so that imaging can be performed with standard, readily available instrumentation. Transaxial tomography with amines is useful in acute cerebral infarction, in which the x-ray computed tomographic scan may be normal for several days after onset of symptoms while the uptake of radioisotope-labeled amines will be altered immediately after the onset of the stroke. It is also useful in examining patients with cerebral vascular disease and in the preoperative examination of patients with partial epilepsy.
- Research Organization:
- Department of Radiology, Harvard Medical School, Boston, MA
- OSTI ID:
- 6195989
- Journal Information:
- Arch. Neurol.; (United States), Vol. 41:10
- Country of Publication:
- United States
- Language:
- English
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Comparison of two cerebral perfusion tracers, N-isopropyl I-123 p-iodoamphetamine and I-123 HIPDM, in the human
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Related Subjects
CEREBRUM
TOMOGRAPHY
IODINE 123
DIAGNOSTIC USES
AMINES
BLOOD FLOW
IMAGES
LABELLED COMPOUNDS
PERFUSED ORGANS
RADIOISOTOPE SCANNING
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics