A new brain perfusion imaging agent: (/sup 123/I)HIPDM:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine
Based on the pH-shift mechanism, a new brain imaging agent /sup 124/I HIPDM (N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-(/sup 123/I)iodobenzyl)-1,3-propanediamine ) has been developed. This agent can be prepared by a simple exchange reaction suitable for routine clinical use. The physicochemical parameters, partition coefficient vs. pH profile, and protein binding, as well as biodistribution in rats, were very similar to those of /sup 123/I IMP (N-isopropyl-p-iodoamphetamine). High brain uptake was found in animals after i.v. injection. The brain radioactivity persists for at least 1 hr in rats and monkeys. Regional distribution in sections of rat brain appeared to reflect regional perfusion. In conjunction with single-photon emission tomography (SPECT), this agent may provide useful information on local cerebral perfusion in humans.
- Research Organization:
- State University of New York, Buffalo
- OSTI ID:
- 6148334
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 24:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BRAIN
AUTORADIOGRAPHY
EMISSION COMPUTED TOMOGRAPHY
IODINE 123
ISOTOPE APPLICATIONS
RADIOPHARMACEUTICALS
RADIOPHARMACEUTICAL
CHEMICAL PREPARATION
IMAGES
LABELLED COMPOUNDS
METABOLISM
PERFUSED TISSUES
PH VALUE
PHYSIOLOGY
RATS
TISSUE DISTRIBUTION
USA
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NORTH AMERICA
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SYNTHESIS
TISSUES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques