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Effect of perphenazine on growth and /sup 65/Zn uptake of the rat prostatic adenocarcinoma, R 3327

Journal Article · · Prostate (N.Y.); (United States)
OSTI ID:6182770
;
Prolactin affects the growth and function of both normal and carcinatomous prostate tissue. Therefore, the effect of modifying prolactin secretion on the growth of the adenocarcinoma of the rat prostate (R3327) was studied, utilizing chronic administration of the dopamine antagonist perphenazine. At 4 and 8 weeks after tumor inoculation, perphenazine (0.5 and 1.0 mg per dose) was injected for 12-16 weeks. Tumors weighed at autopsy showed that the 0.5 mg dose resulted in significantly smaller and the 1.0 mg dose, in significantly larger tumors than the controls. Perphenazine at both doses increased serum prolactin, but the increase was greater when 0.5 mg was administered. There was a higher uptake of /sup 65/Zn when the tumor growth was inhibited as in the animal receiving 0.5 mg of perphenazine. Several possible explanations are offered for the results, including the fact that prolactin might follow a bell-shaped curve in its effect on the tumor and that perphenazine might have other mechanisms of action besides dopamine antagonism.
Research Organization:
Department of Biology, Stern College, Yeshiva University, New York
OSTI ID:
6182770
Journal Information:
Prostate (N.Y.); (United States), Journal Name: Prostate (N.Y.); (United States) Vol. 3:6; ISSN PRSTD
Country of Publication:
United States
Language:
English

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Related Subjects

550901 -- Pathology-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BODY
CARCINOMAS
CHEMISTRY
CHEMOTHERAPY
DAYS LIVING RADIOISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
GONADOTROPINS
HETEROCYCLIC COMPOUNDS
HORMONES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LTH
MALE GENITALS
MAMMALS
NEOPLASMS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGY
PEPTIDE HORMONES
PHARMACOLOGY
PHENAZINE
PITUITARY HORMONES
PROSTATE
PYRAZINES
RADIOISOTOPES
RATS
RODENTS
THERAPY
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
ZINC 65
ZINC ISOTOPES