Radiation sensitivities of R3327-H and R3327-AT rat prostate adenocarcinomas
Dunning R3327-H and R3327-AT tumors growing subcutaneously in the flanks of Fischer X Copenhagen rats were irradiated with /sup 137/Cs gamma-rays at volumes of approximately 300 mm. The effects of various doses of radiation were estimated by measurements of subsequent tumor growth as well as by histological evaluation. The well-differentiated, hormonally-responsive R3327-H tumor was more radiosensitive than the anaplastic R3327-AT tumor. The reasons for this increased radiation sensitivity of the R3327-H tumor include a greater apparent radiation sensitivity of tumor cells and the absence of tumor hypoxia. The presence of hypoxic tumor stem cells was inferred from significant radiosensitization of tumor growth delay by 0.5 mg./gm. misonidazole and by a technique which utilizes radioactively-labelled misonidazole as a marker for hypoxic cells. The persistence of a mass of R3327-H tumor tissue after aggressive radiotherapy was not indicative of tumor cells. Furthermore, the rapid increase in volume of R3327-AT cells after aggressive radiotherapy was attributed to limited proliferation of tumor cells which were destined to ultimately die. Possible implications of these findings for the management of human prostatic adenocarcinoma are discussed.
- Research Organization:
- Cross Cancer Institute, Edmonton, Canada
- OSTI ID:
- 5217522
- Journal Information:
- J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 1; ISSN JOURA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor
Influence of misonidazole on the radiation response of murine tumors of different size: possible artifacts caused by pentobarbital sodium anesthesia
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MODELS
CARCINOMAS
CELL PROLIFERATION
CESIUM 137
CESIUM ISOTOPES
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
ISOTOPES
KINETICS
MAMMALS
MEDICINE
MISONIDAZOLE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
RADIATION DOSES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RATS
REACTION KINETICS
RODENTS
THERAPY
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES