Investigation of different combinations of estrogen therapy and radiation therapy on prostatic adenocarcinoma (R-3327)

Journal Article · Thu May 01 04:00:00 EDT 1980 · Urology (Ridgewood, N.J.); (United States)

DOI:https://doi.org/10.1016/0090-4295(80)90002-3· OSTI ID:5895282

Camuzzi, F; Block, N L; Stover, B; Gottlieb, C; Charyulu, K; Politano, V A

The relative effectiveness of different combinations of estrogen therapy and radiation therapy against the R-3327 prostatic adenocarcinoma of the Copenhagen rat was studied. Because of similar actions of estrogens and radiation in the cell cycle, and possibly antagonistic effects reported in the clinical literature, we looked for an antagonism between these two therapeutic modalities. Radiation therapy consistently showed a greater tumor inhibitory effect than estrogen therapy alone at the dose tested. Combinations of radiation therapy with hormonal manipulation did not appear to show a greater inhibition of tumor growth than radiation therapy alone. There also did not appear to be an antagonistic effect between these two modalities in this system.

• Research Organization: Department of Urology, University of Miami, School of Medicine, Florida
• OSTI ID: 5895282
• Journal Information: Urology (Ridgewood, N.J.); (United States), Journal Name: Urology (Ridgewood, N.J.); (United States) Vol. 15:5; ISSN URGYA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARCINOMAS
DISEASES
ESTROGENS
GLANDS
HORMONES
MALE GENITALS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PROSTATE
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
STEROID HORMONES
SYNERGISM
THERAPY
VERTEBRATES